Hyperthermia is a treatment method in which magnetic carrier particles (such as iron particles) are deposited in the lesion tissue, and the external magnetic field is used to generate the magneto-caloric energy effect to maintain the local temperature to kill the lesion cells without damaging normal cells. At the same time, combined treatment with diagnosis and chemotherapy has better results. Drug factors include chemotherapeutics; Services involved: design prescription conditions, optimize preparation process, sample verification; Physical and chemical indicators: particle size index 100-200nm, stability 3-6 months.