Journal Source

Advanced Materials

Title 

Targeting Endoplasmic Reticulum Stress‑ROS‑Inflammation Cycle With Antibacterial Heterojunctions for Periodontitis Therapy

Research Idea 

This study constructs an endoplasmic reticulum-regulating heterojunction (ERR‑HJ). Aiming at the persistent inflammatory osteolysis in periodontitis caused by refractory biofilms and the vicious cycle of endoplasmic reticulum stress–reactive oxygen species–inflammation, the material achieves bacterial elimination, endoplasmic reticulum homeostasis maintenance and alveolar bone regeneration. Systematic investigations of its physicochemical properties, in vitro cellular and bacterial experiments, and animal models are conducted to decipher the working mechanism.

Highlights 

Different from conventional antibacterial strategies relying on reactive oxygen species production, the heterojunction realizes directional electron transfer at the interface. Electrons derived from hydrogen peroxide in the pathological microenvironment are transported to bacteria to disrupt their respiratory metabolism. Meanwhile, it activates selenoprotein metabolism and interferes with the PERK‑CHOP pathway to break the ER stress‑ROS‑inflammation vicious cycle, combining antibacterial activity and host microenvironment regulation.

Material Development 

(1) Material: ERR‑HJ fabricated from cobalt selenide, Ti₃C₂ MXene and taurine. (2) Functions: Electron-transfer-mediated antibacterial and antibiofilm effects; ROS scavenging, M2 macrophage polarization and osteoclastogenesis inhibition; enhanced osteogenic differentiation of human periodontal ligament cells and alleviation of endoplasmic reticulum stress.

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 17768014569 (Dr.Gao) 

17761925168 (Dr. Zhang) 

18013729810 (Dr. Yang)