The research and application of miRNA nanoprodrugs at the biological interface of burn wounds is an interdisciplinary cutting-edge field. Its primary goal is to use nanomaterials as drug carriers to achieve precise drug delivery, responsive release and microenvironment remodeling by regulating the interactions among inflammatory cells, fibroblasts, extracellular matrix and other components within the wound.


miRNA nanoprodrugs are adopted to achieve early immune regulation of wounds. This nanomedicine consists of a tetrahedral framework self-assembled from DNA molecules, which can carry immunomodulatory miR-146a-5p. After the nanostructure reaches the wound and is internalized by cells, structural rearrangement occurs in response to intracellular RNase H, releasing active miRNA. This further targets and inhibits the TRAF6/NF-κB inflammatory signaling pathway, alleviates excessive inflammation and drives macrophage polarization toward a reparative phenotype.

miRNA nanoprodrugs are used to ameliorate oxidative stress in wounds. This nanomedicine complex exerts regulatory effects in the wound microenvironment, restores the expression of endogenous antioxidant defense systems (such as SOD2, HO-1 and the Nrf2 pathway), and reduces intracellular reactive oxygen species levels. Accordingly, it mitigates the damage of oxidative stress to tissue cells and optimizes the local wound microenvironment.

miRNA nanoprodrugs are applied to achieve anti-fibrosis during the wound remodeling phase. Integrated into the GelMA hydrogel network, these nanoprodrugs achieve local retention and sustained slow release at the wound site. During tissue remodeling, they can effectively suppress excessive fibroblast activation and myofibroblast differentiation, downregulate the pro-fibrotic TGF-β/Smad signaling pathway, reduce excessive extracellular matrix deposition, promote ordered collagen arrangement and skin appendage regeneration, and ultimately facilitate high-quality wound healing.

We provide full-process services for the design of various materials, including highly innovative scheme design, preparation, characterization, and in vitro & in vivo validation (cell/animal experiments). Our postdoctoral team, with multiple high-impact Q1 publications, can tackle your most challenging and sophisticated research needs, covering hydrogels, drug delivery, nanomaterials, polymers, liposomes, microneedle drug delivery and more. We support project design, National Natural Science Foundation of China application, and the publication of high-impact Q1/Q2 papers such as AFM, SCI and AM. Feel free to inquire👇️
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