Research and applications of polymeric nanomedicines at vascular biological interfaces represent a hot interdisciplinary field. Its primary objective is to use polymeric nanomaterials as drug carriers. By modulating their interactions with vascular endothelial cells, blood components, tumor cells and others, targeted drug delivery, controlled release and enhanced therapeutic efficacy can be achieved.


Polymeric nanomedicines can be applied for tumor vascular embolization therapy. This type of polymeric nanomedicine is a nanorobot self-assembled from DNA molecules, which can carry an enzyme capable of inducing blood coagulation, namely thrombin. When the nanorobots reach tumor blood vessels, they are recognized and internalized by receptors on the surface of tumor cells. Subsequently, thrombin is released inside the cells, triggering thrombus formation within tumor blood vessels. This cuts off the nutrient supply to tumors and leads to ischemic necrosis of tumor tissues.


Polymeric nanomedicines can be used for tumor immunotherapy. This polymeric nanomedicine is a complex formed by the confined nanomaterial Gd@C82(OH)22 bound to human complement component C1q protein molecules. Once the complex accumulates at tumor sites, it activates innate immune responses, inducing macrophages and natural killer cells to attack tumor cells. Meanwhile, it stimulates adaptive immune responses and promotes the production of specific antibodies and T cells, achieving multi-level immune clearance of tumors.

Polymeric nanomedicines can be utilized for tumor chemotherapy. This polymeric nanomedicine is a nanozyme composed of multifunctional targeted nanocrystals. It exerts catalytic redox functions in the tumor microenvironment to generate or scavenge free radicals, thereby achieving highly selective killing of tumor cells. It can also ameliorate the hypoxic tumor microenvironment and boost the efficacy of other therapeutic strategies.

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