Recent Strategies and Advances in Hydrogel-Based Delivery Platforms for Bone Regeneration
Recent Strategies and Advances in Hydrogel-Based Delivery Platforms for Bone Regeneration
Bioactive molecules have shown great potential in regulating various bone formation processes, making them an ideal therapeutic option for bone regeneration. However, the widespread application of bioactive molecules is limited by low accumulation and short half-life in the body. Hydrogels have emerged as ideal carriers that can address these challenges and have the potential to prolong the retention time at the lesion site, prolong the half-life in the body, reduce side effects, avoid burst release, and promote absorption under physiological conditions. This review systematically summarizes the latest progress in bioactive molecule-loaded hydrogels in the field of bone regeneration, including applications such as skull defect repair, femoral defect repair, periodontal bone regeneration, and bone regeneration with underlying diseases. In addition, this review discusses existing strategies to improve the release characteristics of bioactive molecules through strategies such as stimuli-responsive delivery, carrier-assisted delivery, and sequential delivery. Finally, this review clarifies the existing challenges and future development directions faced by hydrogel-encapsulated bioactive molecules in the field of bone regeneration.
Innovations:
1. The latest application progress of hydrogel drug delivery systems in the field of bone regeneration is systematically summarized, and a complete treatment strategy system is established.
2. The advantages and characteristics of different delivery strategies are deeply analyzed, and new ideas for performance optimization are proposed.
3. Innovatively proposed a synergistic application strategy of multiple delivery methods to provide a new solution to improve the treatment effect.
Inspiration from scientific research:
1. In the process of material design, the particularity of the physiological environment should be fully considered to develop intelligent responsive materials with specific functions.
2. Scientific research should focus on multidisciplinary cross-integration and combine the advantages of materials science, biomedicine and drug delivery.
3. When designing treatment strategies, attention should be paid to the spatiotemporal regulation of drug delivery to improve the treatment effect.
Idea extension:
1. Material design direction: explore the design and synthesis strategy of new intelligent hydrogels, study multi-responsive materials, and develop synergistic composite systems.
2. Delivery mechanism research: in-depth study of drug release kinetics, explore the relationship between material degradation and drug release, and optimize delivery efficiency.
3. Clinical transformation direction: conduct systematic preclinical research, evaluate biocompatibility, and optimize drug delivery schemes.
4. Intelligent development: develop intelligent controlled release systems, realize on-demand drug delivery, and develop real-time monitoring platforms.
5. Tissue engineering application: explore the combination with tissue engineering scaffolds, study cell-material interaction, and promote tissue regeneration.
6. Industrialization promotion: optimize large-scale production processes, establish a quality control system, and reduce production costs.
7. Treatment strategy optimization: study the synergistic effect of multiple factors, develop personalized treatment plans, and improve treatment effects.
8. Deepen basic research: explore the mechanism of material-cell interaction, study the molecular mechanism of drug delivery, and establish theoretical models.
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