Lymphoma medical-industry intersection - magnetic field-enhanced photothermal ablation of tumor sentinel lymph nodes inhibits cancer metastasis
A magnetically targeted therapeutic strategy for cancer sentinel lymph node metastasis was developed using polyethylene glycol-coated gold-shelled iron oxide nanoclusters as magnetically responsive photothermal agents. This therapeutic strategy, by ablating the primary tumor and sentinel lymph nodes, significantly inhibited lymphoma metastasis and greatly improved the survival rate of animals compared with treatments that only acted on the primary tumor.

Innovation points: 1. Use multi-omics technology (single-cell RNA-seq/ATAC-seq, spatial transcriptomics) for the first time to comprehensively map the molecular heterogeneity of hepatoblastoma; 2. Innovatively divide hepatoblastoma into They are two subtypes with different transcriptional characteristics: "fetal" and "embryonic"; 3. Revealed that the binary expression patterns of HNF4A and LEF1 can accurately distinguish tumor cell subtypes; 4. Determine pertinence through systematic screening of patient-derived organoids Targeted therapy drugs.

Scientific research inspiration: 1. Demonstrated the great value of multi-omics integrated analysis in precision cancer medicine; 2. Revealed the key impact of tumor heterogeneity on targeted therapy; 3. Provided new strategies for personalized treatment based on molecular characteristics ; 4. Proves the important role of tumor organoids in drug screening.

Extension of ideas: 1. Explore the application of similar multi-omics analysis methods in other children's tumors; 2. Study the deep regulatory mechanism of WNT signaling pathway in tumorigenesis; 3. Develop precise treatment options based on molecular subtypes; 4. Explore The synergistic therapeutic potential of HDAC, FGFR and EGFR inhibitors; 5. In-depth analysis of the abnormal expression mechanism of liver development-related genes in tumors; 6. Design of more accurate molecular classification and treatment strategies; 7. Research on the role of tumor organoids in personalization Long-term value in medication.