Multi-barrier programmed nanodelivery strategies and real-time detection devices

跨多屏障程序化纳米递送策略是一种利用纳米材料和外部刺激来实现药物或基因在体内的精准、可控和高效的递送的技术,它可以克服生理屏障、细胞屏障和核屏障等多种阻碍,从而提高药物的生物利用度和治疗效果。程序化纳米递送策略可以根据药物的性质、目标组织的特征、病理状态的变化等因素,设计不同的响应机制和释放模式,以实现药物的定时、定量、定向和定位的递送。

实时检测器件是一种利用光学、电化学、生物传感等手段来监测纳米递送系统在体内的分布、运输、释放和作用的技术,它可以提供对纳米递送系统的实时反馈和调控,从而优化药物的疗效和安全性。实时检测器件可以与纳米递送系统结合,形成一体化的智能平台,或者单独使用,作为辅助工具来评估纳米递送系统的性能。
Multi-barrier programmed nanodelivery strategy is a technique that enables precise, controlled, and efficient delivery using nanomaterials and external stimuli, which can overcome multiple obstacles such as physiological, cellular, and nuclear barriers, thus improving drug bioavailability and therapeutic efficacy. Programmed nanodelivery strategies can design different response mechanisms and release patterns based on the nature of the drug, characteristics of the target tissue, and changes in pathological state, to achieve timing, quantitative, directed, and localized delivery of drugs.

Real-time detection device is a technology that monitors the distribution, transportation, release and action of the nanodelivery system by using optics, electrochemical and biosensing means in the body. It can provide real-time feedback and regulation of the nanodelivery system, so as to optimize the efficacy and safety of drugs. Real-time detection devices can be combined with nanodelivery systems to form an integrated intelligent platform or, used alone, as an auxiliary tool to evaluate the performance of the nanodelivery system.

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