Audio and optical diagnosis and treatment drug and equipment is a new method to realize the diagnosis and treatment of tumors by using the synergistic effect of acoustic waves and light waves. Audio-optical diagnosis and treatment drug is a special photosensitizer, which can produce singlet oxygen and other reactive oxygen species under the excitation of sound waves, and produce toxic effects on tumor cells. Audio-optical diagnosis and treatment equipment is an instrument that can emit both sound and light waves, which can realize the positioning, imaging and killing of tumors. Treatment of head and neck squamous cell carcinoma based on sound and light diagnosis and equipment: Sonofotodin (SFD) acoustic medication and Sonolux (SLX) acoustic and light diagnosis and treatment equipment for the treatment of head and neck squamous cell carcinoma patients. SFD is a drug based on porphyrin derivatives, which can produce reactive oxygen species under the joint action of sound waves and light waves. SLX, a device capable of simultaneously emitting 1 MHz ultrasound and 630 nm red light, enables the localization, imaging, and killing of tumors. Treatment of gastric cancer based on acoustic and optical diagnosis and treatment: a sound and optical treatment drug called platinum porphyrin (PtCP) and an acoustic and optical treatment device called endoscopic ultrasound (EUS) to treat patients with gastric cancer. PtCP is a drug treatment based on platinum porphyrin derivatives, which can produce reactive oxygen species under the joint action of sound waves and light waves. EUS, a device capable of simultaneously emitting 20 MHz ultrasound and 635 nm red light, enables localization, imaging and killing of the tumor. Treatment of prostate cancer based on acoustic and optical diagnosis and treatment equipment: acoustic and optical treatment drugs for platinum porphyrin (PtCP) and acoustic and optical treatment equipment for ultrasound catheter (USC) to treat prostate cancer patients. PtCP is a drug treatment based on platinum porphyrin derivatives, which can produce reactive oxygen species under the joint action of sound waves and light waves. USC, a device capable of simultaneously emitting 1 MHz ultrasound and 670 nm red light, enables positioning, imaging and killing of tumors.