The functional design of metal-organic frame nanoparticles and the application of tumor therapy is a new nanomedicine technology that uses the porous structure of nanoparticles, high specific surface area, tunability and biocompatibility to realize the multimodal diagnosis and multi-mode treatment of tumors. Metal-organic frame nanoparticles can be used as carriers of drugs, photothermal agents, photosensitizers, Fenton reaction catalysts, etc., to achieve targeted treatment of tumors through external light, acoustic and magnetic stimulation, and can also be used as imaging agents to achieve visual diagnosis of tumors through photoacoustic, CT, MRI and other means. The functional design of metal-organic frame nanoparticles and the application research of cancer therapy are noninvasive, efficient, low-toxic and multi-functional.