自适应MTSNPs
| 【Numbering】BKMC102003 | 【CAS】CAS | ||
| 【Item No.】BKMC102003-2 | 【specification】 | ||
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Name: Adaptive MTSNPs
Composition: PLGA, melatonin, cDNA, and VE GF
Size: 100-200nm
Application: Administration on demand after myocardial ischemic injury
Storage conditions: -4℃
Other instructions: You will have a shelf life of half a year in the sealed state
[Main advantages] 1. In terms of function, The cytoprotective mechanisms of the melatonin core to mimic MT, MT can naturally synthesize melatonin to resist ischemia; Circular DNA mimics the biological oxygen-sensing mechanism, Synthesis of vascular endothelial growth factor (VE GF) based on the oxygen level for blood vessel formation, Just like MT provides ATP according to the needs of the microenvironment; 2, in the acute phase of ischemia, The MTSNP rapidly releases melatonin, Elimination of reactive oxygen species, Activation of the melatonin receptor I on the MT, Preventing the release of cytochrome c, Thus activating cell apoptosis; 3, in the chronic phase, The circular DNA can sense hypoxia, And actively secreted VE GF for revascularization.
Title:Mitochondria-Inspired Nanoparticles with Microenvironment-Adapting Capacities for On-Demand Drug Delivery after Ischemic Injury
Article link:http://www.nanoer.net/showinfo-4-22977.html
Message
Composition: PLGA, melatonin, cDNA, and VE GF
Size: 100-200nm
Application: Administration on demand after myocardial ischemic injury
Storage conditions: -4℃
Other instructions: You will have a shelf life of half a year in the sealed state
[Main advantages] 1. In terms of function, The cytoprotective mechanisms of the melatonin core to mimic MT, MT can naturally synthesize melatonin to resist ischemia; Circular DNA mimics the biological oxygen-sensing mechanism, Synthesis of vascular endothelial growth factor (VE GF) based on the oxygen level for blood vessel formation, Just like MT provides ATP according to the needs of the microenvironment; 2, in the acute phase of ischemia, The MTSNP rapidly releases melatonin, Elimination of reactive oxygen species, Activation of the melatonin receptor I on the MT, Preventing the release of cytochrome c, Thus activating cell apoptosis; 3, in the chronic phase, The circular DNA can sense hypoxia, And actively secreted VE GF for revascularization.
Title:Mitochondria-Inspired Nanoparticles with Microenvironment-Adapting Capacities for On-Demand Drug Delivery after Ischemic Injury
Article link:http://www.nanoer.net/showinfo-4-22977.html
| Warm tips: Suzhou Beike nano products are only used for scientific research, not for human body,different batches of products have different specifications and performance |
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