自组装结构Mito-PISA
| 【Numbering】BKMC102002 | 【CAS】CAS | ||
| 【Item No.】BKMC102002-2 | 【specification】 | ||
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Name: Self-assembled structure Mito-PISA
Composition: aromatic molecule monomer, TPP
Particle size: network shape, diameter of 50-100nm
Application: Regulation of cancer cells
Storage conditions: -4℃
Other instructions: shelf life of half a year in sealed state [main advantages]
1, high reactive oxygen species (ROS) concentrations in tumor mitochondria can lead to the formation of polymeric disulfide bonds. Because of the reducing environment, this polymerization hardly takes place elsewhere in the cell. It was shown that polymerization of thiol-containing monomers would further increase ROS levels within the mitochondria, which automatically catalyzes the polymerization process and generating fibrous-like polymerization structures.
(2) Experimental results show that this process will induce mitochondrial dysfunction, and then activate cell necrosis. In conclusion, this in situ polymerization system has broad potential for cancer treatment and against drug-resistant cancers.
Title:Intramitochondrial Disulfide Polymerization Controls Cancer Cell Fate
Article link:https://www.sogou.com/link?url=DSOYnZeCC_qqiTNYDsEp-hN55sPA_JdbNUqAS-fQLJrr3xX9ZTojqbbAp6VRqT6Q
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Composition: aromatic molecule monomer, TPP
Particle size: network shape, diameter of 50-100nm
Application: Regulation of cancer cells
Storage conditions: -4℃
Other instructions: shelf life of half a year in sealed state [main advantages]
1, high reactive oxygen species (ROS) concentrations in tumor mitochondria can lead to the formation of polymeric disulfide bonds. Because of the reducing environment, this polymerization hardly takes place elsewhere in the cell. It was shown that polymerization of thiol-containing monomers would further increase ROS levels within the mitochondria, which automatically catalyzes the polymerization process and generating fibrous-like polymerization structures.
(2) Experimental results show that this process will induce mitochondrial dysfunction, and then activate cell necrosis. In conclusion, this in situ polymerization system has broad potential for cancer treatment and against drug-resistant cancers.
Title:Intramitochondrial Disulfide Polymerization Controls Cancer Cell Fate
Article link:https://www.sogou.com/link?url=DSOYnZeCC_qqiTNYDsEp-hN55sPA_JdbNUqAS-fQLJrr3xX9ZTojqbbAp6VRqT6Q
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