OA-Ir/OA-Ru
| 【Numbering】BKME110000 | 【CAS】CAS | ||
| 【Item No.】BKME110000-2 | 【specification】 | ||
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Name: OA-Ir / OA-Ru
Composition: Ir-N3 or Ru-N3 + OA-Alkyne
grain size:
Application: anti-tumor and tumor metastasis
Storage conditions: -4℃
Other instructions: shelf life of half a year under sealed state [Main advantages] The coupling of onolic acid (OA) and metal aromatics significantly enhanced the cytotoxicity of A2780 cells. Furthermore, both complexes can inhibit cell metastasis and invasion by disrupting actin dynamics and downregulation of MMP 2 / MMP 9 protein. The combination of the two precursors improved lipophilicity and biocompatibility while enhancing cellular uptake and mitochondrial accumulation of metal-arene complexes, causing potential damage to mitochondrial membranes, oxidative phosphorylation, ATP depletion, and autophagy.
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Composition: Ir-N3 or Ru-N3 + OA-Alkyne
grain size:
Application: anti-tumor and tumor metastasis
Storage conditions: -4℃
Other instructions: shelf life of half a year under sealed state [Main advantages] The coupling of onolic acid (OA) and metal aromatics significantly enhanced the cytotoxicity of A2780 cells. Furthermore, both complexes can inhibit cell metastasis and invasion by disrupting actin dynamics and downregulation of MMP 2 / MMP 9 protein. The combination of the two precursors improved lipophilicity and biocompatibility while enhancing cellular uptake and mitochondrial accumulation of metal-arene complexes, causing potential damage to mitochondrial membranes, oxidative phosphorylation, ATP depletion, and autophagy.
Title:Unlocking the potential of iridium and ruthenium arene complexes as anti-tumor and anti-metastasis chemotherapeutic agents
Article link:https://doi.org/10.1016/j.jinorgbio.2022.112057| Warm tips: Suzhou Beike nano products are only used for scientific research, not for human body,different batches of products have different specifications and performance |
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| Warm tips: Suzhou Beike nano products are only used for scientific research, not for human body,different batches of products have different specifications and performance.The website pictures are from the Internet. The pictures are for reference only. Please take the real object as the standard. In case of infringement, please contact us to delete them immediately. |
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