FCS/GCS
| 【Numbering】BKMC106002 | 【CAS】CAS | ||
| 【Item No.】BKMC106002-2 | 【specification】 | ||
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Name: FCS / GCS
Composition: amphiphilic polymer backbone (P-SS-D) + cassia bark aldehyde prodrug (CA-OH) + iron ion (Fe3 +) / gadolinium ion (Gd 3 +) + polyphenols
Size: 300-500nm
Application: anti-tumor
Storage conditions: -4℃
Other instructions: shelf life of half a year under sealed state [Main advantages] In the poly (disulfide) backbone of P-SS-D of nanoparticles at high GSH levels. Activated CA depletes GSH, elevating intracellular H2O2, and subsequent high levels of Fenton reaction produce abundant OH levels. The production of reactive oxygen species (ROS) further accelerates CA activation. Disulfide, CA, and Fe3 + deplete GSH, downregulate GPX 4 and produce OH, thus accelerating the accumulation of lipid peroxide (LPO) and enhance iron death.
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Composition: amphiphilic polymer backbone (P-SS-D) + cassia bark aldehyde prodrug (CA-OH) + iron ion (Fe3 +) / gadolinium ion (Gd 3 +) + polyphenols
Size: 300-500nm
Application: anti-tumor
Storage conditions: -4℃
Other instructions: shelf life of half a year under sealed state [Main advantages] In the poly (disulfide) backbone of P-SS-D of nanoparticles at high GSH levels. Activated CA depletes GSH, elevating intracellular H2O2, and subsequent high levels of Fenton reaction produce abundant OH levels. The production of reactive oxygen species (ROS) further accelerates CA activation. Disulfide, CA, and Fe3 + deplete GSH, downregulate GPX 4 and produce OH, thus accelerating the accumulation of lipid peroxide (LPO) and enhance iron death.
Title:A tumor microenvironment responsive nanoplatformwith oxidative stress amplification for effective MRI-based visual tumor ferroptosis
Article link:DOl: 10.1016/j.actbio.2021.11.007
| Warm tips: Suzhou Beike nano products are only used for scientific research, not for human body,different batches of products have different specifications and performance |
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