BSO/ZIF-8@Au@MPN@HA
| 【Numbering】BKMC106000 | 【CAS】CAS | ||
| 【Item No.】BKMC106000-2 | 【specification】 | ||
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Name: BSO / ZIF-8 @ Au @ MPN @ HA
Composition: l-buthionine-sulfoxide (BSO) + Fe ion + ZIF-8 + HA + gold nanoparticles
Size: 100-300nm
Application: Enhance the effect of radiotherapy
Storage conditions: -4℃
Other instructions: shelf life of half a year under sealed state [Main advantages] Tumor microenvironment (TME) can degrade nanohybrids, combined with iron apoptosis induction and high-z effect based on metal-organic frame, for iron apoptosis enhanced RT in TNBC. The l-butanionine-sulfoxide (BSO) can inhibit the biosynthesis of glutathione (GSH), inactivate glutathione peroxidase 4 (GPX 4), thus destroying the apoptosis defense system. The delivered ferrous ion can become a potent apoptosis executor by triggering Fenton reaction; the combination can induce potent ferroptosis and cooperate with the radiosensitization mediated by surface-modified gold (Au) nps to improve the efficacy of radiotherapy.
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Composition: l-buthionine-sulfoxide (BSO) + Fe ion + ZIF-8 + HA + gold nanoparticles
Size: 100-300nm
Application: Enhance the effect of radiotherapy
Storage conditions: -4℃
Other instructions: shelf life of half a year under sealed state [Main advantages] Tumor microenvironment (TME) can degrade nanohybrids, combined with iron apoptosis induction and high-z effect based on metal-organic frame, for iron apoptosis enhanced RT in TNBC. The l-butanionine-sulfoxide (BSO) can inhibit the biosynthesis of glutathione (GSH), inactivate glutathione peroxidase 4 (GPX 4), thus destroying the apoptosis defense system. The delivered ferrous ion can become a potent apoptosis executor by triggering Fenton reaction; the combination can induce potent ferroptosis and cooperate with the radiosensitization mediated by surface-modified gold (Au) nps to improve the efficacy of radiotherapy.
Title:A MOF-based Potent Ferroptosis Inducer for Enhanced Radiotherapy of Triple Negative Breast Cancer
Article link:https://doi.org/10.1021/acsnano.3c00048
| Warm tips: Suzhou Beike nano products are only used for scientific research, not for human body,different batches of products have different specifications and performance |
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