Bioprobe：BBT-IR/Se-MN
| 【Numbering】BKMD103003 | 【CAS】CAS | ||
| 【Item No.】BKMD103003-2 | 【specification】 | ||
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Name: BBT-IR / Se-MN
Raw material: organic disselenium compound + nitrol compound + benzothiadiazole group (BBT) + ROS-responsive fluorophore IR emission wavelength: 1050nm Application: ROS detection and enhanced radiotherapy
Storage conditions: -4℃
Other instructions: shelf life of half a year in sealed state [Main advantages] BBT-IR / Se-MN enhances radiotherapy effects through various mechanisms and self-monitoring of ROS levels in the tumor. Upon x-ray irradiation, diselenides produce high levels of ROS, leading to enhanced DNA damage in cancer cells. Then, the nitroimidazole in the molecule inhibits impaired DNA repair, providing a synergistic radiosensitizing effect of cancer. Furthermore, the probe showed low and high NIR-II fluorescence ratios in the absence of ROS and in the presence of ROS, which is suitable for precise quantitative monitoring of ROS during sensitized RT.
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Raw material: organic disselenium compound + nitrol compound + benzothiadiazole group (BBT) + ROS-responsive fluorophore IR emission wavelength: 1050nm Application: ROS detection and enhanced radiotherapy
Storage conditions: -4℃
Other instructions: shelf life of half a year in sealed state [Main advantages] BBT-IR / Se-MN enhances radiotherapy effects through various mechanisms and self-monitoring of ROS levels in the tumor. Upon x-ray irradiation, diselenides produce high levels of ROS, leading to enhanced DNA damage in cancer cells. Then, the nitroimidazole in the molecule inhibits impaired DNA repair, providing a synergistic radiosensitizing effect of cancer. Furthermore, the probe showed low and high NIR-II fluorescence ratios in the absence of ROS and in the presence of ROS, which is suitable for precise quantitative monitoring of ROS during sensitized RT.
Title:A Radio-Pharmaceutical Fluorescent Probe for Synergistic Cancer Radiotherapy and Ratiometric Imaging of Tumor Reactive Oxygen Species
Article link:DOI: 10.1002/anie.202305744
| Warm tips: Suzhou Beike nano products are only used for scientific research, not for human body,different batches of products have different specifications and performance |
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| Warm tips: Suzhou Beike nano products are only used for scientific research, not for human body,different batches of products have different specifications and performance.The website pictures are from the Internet. The pictures are for reference only. Please take the real object as the standard. In case of infringement, please contact us to delete them immediately. |
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