Name: BP @ Ec-T
Composition: Escherichia coli MG1655 + black phosphorus (BP) nanoparticles
Dimension: micron level
Application: Tumor therapy
Storage conditions: -4℃
Other instructions: Half shelf life in sealed state [Main advantage] The bacterium expresses tumor necrosis factor-related apoptosis-induced ligand (TRAIL) through the outer membrane YiaT protein (Ec-T). It can transfer the photoelectrons generated by BP NPs after laser irradiation and trigger the nitrate reduction metabolism of nitric oxide, released in situ at the tumor site, promoting the therapeutic effect and polarization of tumor-associated macrophages to the M1 phenotype. Meanwhile, the production of reactive oxygen species induces immunogenic cell death, further enhancing its antitumor efficacy.
Title:Surface programmed bacteria as photo-controlled NO generator for tumor
immunological and gas therapy
Article link:https://doi.org/10.1016/j.jconrel.2022.12.030
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