Water-soluble gold nanocage
| 【Numbering】BKNMAuC01 | 【CAS】7440-57-5 | ||
| 【Item No.】AuC01-0100 | 【specification】 | ||
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Introduction】
Gold nanocage is a new type of hollow and porous advanced nanomaterials of precious metals. Because of its excellent surface plasmon resonance (SPR) characteristics, it has been extensively studied in many fields such as biological and chemical sensing, surface enhanced Raman scattering, and information storage. In the field of biomedicine, the surface plasmon resonance (SPR) peak of gold nanocage is more sensitive to changes in the dielectric properties of the surrounding environment (including solvents, adsorbed substances, and the distance between particles) than gold nanoparticles. A more potential detection platform for biomolecules based on changes in local SPR peaks. By accurately modulating the size and aperture ratio of the gold nanocage, the SPR peak position can be easily transformed from the visible light region to the near-infrared region. Since water and hemoglobin have almost no absorption of light waves in this wavelength range, they are expected to be used to detect whole blood samples. Compared with the plasmon resonance of solid gold nanoparticles only localized on the surface, gold nanocages can achieve plasmon resonance absorption on both the outer surface and the inner surface due to their hollow characteristics, so they can be used as a more excellent light Heat conversion agent for tumor hyperthermia. It needs to be particularly pointed out that due to the hollow and porous nature of the gold nanocage, it can be combined with temperature-sensitive molecules and combined with the assistance of external fields such as near-infrared lasers to become a highly efficient nano-drug loading and sustained-release nano platform. Compared with gold nanoshells with solid silica spheres as the core and other solid nanomaterials, gold nanocages have greater advantages in efficient drug loading. In addition, the porous structure on the surface of the gold nanocage greatly increases its “hot spots” as a surface-enhanced Raman scattering substrate. In addition, the electromagnetic field enhancement effect caused by the superimposed plasmon resonance on the inner and outer surfaces makes it a The widely used surface-enhanced Raman scattering substrate is expected to realize single-molecule detection based on surface-enhanced Raman scattering in the liquid phase.
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Gold nanocage is a new type of hollow and porous advanced nanomaterials of precious metals. Because of its excellent surface plasmon resonance (SPR) characteristics, it has been extensively studied in many fields such as biological and chemical sensing, surface enhanced Raman scattering, and information storage. In the field of biomedicine, the surface plasmon resonance (SPR) peak of gold nanocage is more sensitive to changes in the dielectric properties of the surrounding environment (including solvents, adsorbed substances, and the distance between particles) than gold nanoparticles. A more potential detection platform for biomolecules based on changes in local SPR peaks. By accurately modulating the size and aperture ratio of the gold nanocage, the SPR peak position can be easily transformed from the visible light region to the near-infrared region. Since water and hemoglobin have almost no absorption of light waves in this wavelength range, they are expected to be used to detect whole blood samples. Compared with the plasmon resonance of solid gold nanoparticles only localized on the surface, gold nanocages can achieve plasmon resonance absorption on both the outer surface and the inner surface due to their hollow characteristics, so they can be used as a more excellent light Heat conversion agent for tumor hyperthermia. It needs to be particularly pointed out that due to the hollow and porous nature of the gold nanocage, it can be combined with temperature-sensitive molecules and combined with the assistance of external fields such as near-infrared lasers to become a highly efficient nano-drug loading and sustained-release nano platform. Compared with gold nanoshells with solid silica spheres as the core and other solid nanomaterials, gold nanocages have greater advantages in efficient drug loading. In addition, the porous structure on the surface of the gold nanocage greatly increases its “hot spots” as a surface-enhanced Raman scattering substrate. In addition, the electromagnetic field enhancement effect caused by the superimposed plasmon resonance on the inner and outer surfaces makes it a The widely used surface-enhanced Raman scattering substrate is expected to realize single-molecule detection based on surface-enhanced Raman scattering in the liquid phase.
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