Recombinant human epidermal growth factor

Recombinant human epidermal growth factor

【Numbering】BK-NRPA11S 【CAS】CAS
【Item No.】BK-NRPA11S-1 【specification】
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Name: Recombinant human epidermal growth factor


Specifications: 10 μg, 100 μg, 1 mg, 10mg, special order


Product form: Lyophilized powder, the solution before lyophilization is 2.5 mM Na2HPO4, 2.5 mM NaH2PO4, 2% mannitol, pH 6.8 solution


Molecular weight: 6.2 kDa


Isoelectric point: 4.78


Source: Escherichia coli


Purity: ≥95% (SDS-PAGE and SEC-HPLC)


Endotoxin: ≤5 EU/mg


Activity: 1 mg≥1*106 U; EC50≤0.1 ng/ml (BALB/c 3T3 cell detection)


Storage conditions: -20℃ storage


Validity period: 3 years




Related introduction:


Mature human epidermal growth factor (hEGF) is a single-chain low-molecular-weight polypeptide composed of 53 amino acids, with a molecular weight of about 6.2 kDa, containing 6 cysteines in the molecule, and forming 3 pairs of disulfide bonds in the chain. , Alkali and heat are relatively stable, and can withstand the degradation of trypsin, chymotrypsin and pepsin and other enzymes. It is one of the most stable protein peptides known. hEGF exerts a variety of biological functions by binding to the specific EGF receptor (EGFR) on the cell surface, and can be used clinically to treat surgical trauma, skin ulcers, digestive tract ulcers, corneal injuries, tissue repair, etc.






hEGF can automatically bind to the EGFR on the cell membrane near the wound, thereby activating protein kinase, accelerating the synthesis of DNA, RNA and protein, promoting and regulating the growth and value of epidermal cells, allowing the wound to heal quickly and repairing skin tissue. Therefore, adding hEGF to cosmetics has the functions of removing scars, acne, and acne. hEGF also has a protective effect on normal skin, mainly in the aspects of delaying aging, increasing skin elasticity and luster.






The recombinant human epidermal growth factor (rh-EGF) is expressed by extracellular secretion, and the amino acid sequence and molecular structure remain consistent with the natural hEGF, and it has complete biological activity.


图片16.jpg


M: protein molecular weight standard


Lane 1: rh-EGF





图片17.jpg







rh-EGF stimulates the proliferation of BALB/c 3T3 cells (MTT method) 


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